途游斗地主

EN

途游斗地主YAOWUYANFACHIXUTUIJIN,PANDIANYOUWANGZHIFUXINGUANFEIYANDESIDAZHAOSHU

ZIXINGUANFEIYAN(COVID-19)BAOFAYILAI,YICHENGXIANCHUQUANQIUMANYANDETAISHI,PUTONGMINZHONGQIDAIYOUXIAOYAOWUDEFAXIAN,YIZAORIZHONGJIEZHEICHANGHAOJIE。ZHENDUI SARS-CoV-2 DEYAOWUKAIFA,KEYANRENYUANHESHENGWUZHIYAOQIYEGEXIANSHENTONG,SHIZHANDEZHAOSHUZHUYAOKEGUINAWEISILEI:

途游斗地主1. CESHIXIANYOUDEKANGBINGDUYAOWU(LAOYAOXINYONG)

途游斗地主2. SHAIXUANXIAOFENZIHUAHEWUKU

途游斗地主3. JIYUGUANZHUANGBINGDUDEZUOYONGJILIKAIFATEYIZHENDUIXINXINGGUANZHUANGBINGDUDEYAOWU

途游斗地主4. JIYUXINGUANFEIYANFEIBUBINGBIANDEBINGLIJIZHIYANFAJIANQINGFEIBUBINGBIANZHENGZHUANGYAOWU

 

测试现有的抗病毒药物(老药新用)

ZHONGXINYANFAYIGEANQUANYOUXIAODEYAOWUSHIXIANGDANGHAOSHIDE,DUIYUTUFADEYIQING,「LAOYAOXINYONG」YEXUKEJIERANMEIZHIJI。YIYOUHUOZHENGZAIJINXINGLINCHUANGYANJIUDEYAOWU,QIANZAIYAOXIAOHEFUZUOYONGDOUXIANGDUIMINGQUE,JIDADISUODUANLEYANFAHELINCHUANGCESHIDESHIJIAN。

DUIYUCICIXINGUANFEIYANYIQING,CESHIYONGYUKANGJI SARS-CoV(YANZHONGJIXINGHUXIZONGHEZHENGBINGDU)、MERS-CoV(ZHONGDONGHUXIZONGHEZHENGBINGDU)、AIBOLAHEAIZIBINGDUDENGKANGBINGDUYAOWUYIJINGCHENGWEIZHONGYAOFANGFA。

途游斗地主RUXIANZAIBEISHOUGUANZHUDERUIDEXIWEI(Remdesivir)ZHILIAOAIBOLAHUANZHEZAIMEIGUOYIJINGWANCHENGLE III QILINCHUANGSHIYAN,XIAOGUOLIANGHAO,MUQIANZAIZHONGGUOYIQIDONGXINGUANFEIYANZHILIAODELINCHUANGYANJIU;

KELIZHI(Aluvia/Kaletra)YIZAIMEIGUOSHANGSHIYONGYUZHILIAO HIV,YUGANRAOSULIANHEYONGYAOYEYIZAIZHONGGUOLINCHUANGSHIYANZHONGXINZHUCE;

途游斗地主ABIDUOER(Arbidol)YIZAIZHONGGUOSHANGSHIYONGYUBINGDUXINGLIUGANBINGRENDEZHILIAO。

ZAILAOYAOXINYONGDEYANFAZHONG,Bio-Techne DEXIBAOYINZIJIANCEXIANGGUANCHANPINYONGYUJIANCEYONGYAOHOUXIBAOYINZIFENGBAODEQINGKUANG。HUXIDAOLEIQIGUANDEPEIYANGNENGGOUGENGZHENSHIDIMONITINEIDEZUZHIQIGUANHUANJING,GENGJINGZHUNDIJINXINGYAOXIAOPINGGU。RNAscope® JISHUKEDUIBINGDUZAISHENGWUTIZHONGYINGGUANGYUANWEIJIANCE,DUIBINGDUJINXINGSHENRUYANJIU。

类器官培养产品

筛选小分子化合物库

途游斗地主CONGYIYOUDEXIAOFENZIHUAHEWUKUSHAIXUANCHUJUYOUKANGXINGUANBINGDUQIANLIDEXIAOFENZIHUAHEWUJINXINGYAOWUDEYANFAYESHIXIAOLVJIAOGAODEFANGFA。

途游斗地主Bio-Techne QIXIADE Tocris® PINPAITIGONGDEHUAHEWUWENKU,BAOHAN 1,280 ZHONGSHENGWUHUOXINGHUAHEWU,HANGAIGUANGFANDEYAOWUZUOYONGBADIANHEYINGYONGLINGYU,KEYONGYUKANGXINGUANBINGDUDESHAIXUAN。

 

基于冠状病毒的作用机理开发特异针对新型冠状病毒的药物

途游斗地主SARS-CoV-2 HE SARS-CoV TONGYUANXINGYUEWEI 80%,MUQIANYANJIUXIANSHI,SARS-CoV-2 HE SARS-CoV DOUSHITONGGUOBINGDUBIAOMIANDECITUDANBAI(Spike)YURENTINIANMOXIBAOBIAOMIANDE ACE2(XUEGUANJINZHANGSUMEI 2)JIEHESHIBINGDUYUSUZHUXIBAOMOFASHENGRONGHEJINRUXIBAO,ZAIJINGYOUSUZHUXIBAODEDANBAIMEI TMPRSS2、Cathepsin B/L QIEGE Spike DANBAISHIBINGDUSHIFANGCHU RNA。

BINGDU RNA JINRUXIBAONEI,FUZHIBINGZUZHUANGWANCHENGHOU,HUIBEI ACE2 LIANZAIXIBAOMOSHANG,ACE2 BEIKUAMODANBAIMEI(ADAM17)JIANDUAN,BINGDUJIUKEYILIKAISUZHUXIBAOJIXUXIAYILUNDEQINXI。

SARS-CoV 进入宿主示意图    来源:doi: 10.1128/JVI.02202-13.

 

途游斗地主SARS-CoV-2 DEZUOYONGJILIXIANSHI Spike、ACE2、TMPRSS2、Cathepsin B/L HE ADAM17 SHIKANG SARS-CoV-2 BINGDUYAOWUDEQIANZAIBADIAN,JIYUZHEIXIEDANBAIYANFACHUDEZHONGHEZUDUANKANGTIHEYIZHIJIYOUWANGCHENGWEIZHILIAOXINGUANFEIYANDEYOUXIAOYAOWU。

 

Bio-Techne 可提供研发这些药物相应的产品:

此外还有:

TMPRSS2 重组蛋白

货号

品名

表达体系

H00007113-Q01

Recombinant Human TMPRSS2 Protein

Wheat germ

NBP2-38263PEP

TMPRSS2 Recombinant Protein Antigen

E. coli

NBL1-17121

TMPRSS2 Overexpression Lysate

HEK293T

TMPRSS2 抗体

货号

品名

应用

NBP1-20984

TMPRSS2 Antibody

WB, PEP-ELISA

H00007113-M05

TMPRSS2 Antibody (2F4)

WB, ELISA

H00007113-B01P

TMPRSS2 Antibody

WB

Spike 抗体

货号

品名

应用

NB100-56578

Sars Spike Protein Antibody

WB, ICC/IF

NB100-56047

Sars Spike Protein Antibody

WB, ELISA

NBP2-24942

Sars Spike Protein Antibody (17F706)

WB

NBP2-24746

Sars Spike Protein Antibody (16F1071)

WB, ICC/IF

NB100-56048

Sars Spike Protein Antibody

WB, ELISA

NB100-56684

Sars Spike Protein Antibody

WB

NB100-56685

Sars Spike Protein Antibody

WB

NB100-56589

Sars Spike Protein Antibody

WB

NBP2-24808

Sars Spike Protein Antibody

ELISA

Cathepsin B/L 重组蛋白

货号

品名

表达体系

953-CY

RecombinaNS0nt Human Cathepsin B Protein, CF

NS0

952-CY

Recombinant Human Cathepsin L Protein, CF

NS0

1515-CY

Recombinant Mouse Cathepsin L Protein, CF

NS0

965-CY

Recombinant Mouse Cathepsin B Protein, CF

NS0

NBP1-99197

Human Cathepsin B Native Protein

Human liver

NBP2-53084

Recombinant Mouse Cathepsin B Protein

Baculovirus

Cathepsin B/L 抗体

货号

品名

应用

AF953

Human Cathepsin B Antibody

IHC, IP, KO, Simple Western, WB

AF965

Mouse Cathepsin B Antibody

B/N, IHC, WB

BAF965

Mouse Cathepsin B Biotinylated Antibody

IHC, WB

MAB965

Human/Mouse Cathepsin B Antibody

WB

BAF953

Human Cathepsin B Biotinylated Antibody

ELISA(Det), IHC, WB

NBP1-19797

Cathepsin B Antibody

WB, ICC/IF, IHC, IHC-P

NBP1-86048

Cathepsin B Antibody

ICC/IF, IHC, IHC-P

NBP2-67215

Cathepsin B Antibody (JA11-02)

WB, ICC/IF, IHC, IHC-P

NBP1-25931

Cathepsin B Antibody [FITC]

ELISA

AF1515

Mouse/Rat Cathepsin L Antibody

IHC, Simple Western, WB

AF952

Human Cathepsin L Antibody

ELISA(Cap), IHC, IP, WB

MAB9521

Human/Mouse Cathepsin L Antibody

IHC, IP, WB

MAB952

Human Cathepsin L Antibody

IHC, WB

BAF952

Human Cathepsin L Biotinylated Antibody

ELISA(Det), WB

BAF1515

Mouse Cathepsin L Biotinylated Antibody

WB

NB100-1775

Cathepsin L Antibody (33/2)

WB, ELISA, ICC/IF, IHC, IHC-Fr, MiAr

NBP2-67216

Cathepsin L Antibody (JM10-78)

WB, Flow, ICC/IF, IHC, IHC-P

Cathepsin B/L 小分子化合物

货号

品名

描述

0448/10

Calpeptin

Calpain and cathepsin L inhibitor

3625/10

SID 26681509

Cathepsin L inhibitor

4863/1

CA 074

Selective cathepsin B inhibitor

Cathepsin B/L 检测试剂盒

货号

品名

描述

DCATB0

Human Pro-Cathepsin B Quantikine ELISA Kit

 

DY2176

Human Total Cathepsin B DuoSet ELISA

 

DY952

Human Cathepsin L DuoSet ELISA

 

KA0552

Human Cathepsin B ELISA Kit (Colorimetric)

 

NBP2-67254

Mouse Cathepsin B ELISA Kit (Colorimetric)

 

NBP2-67255

Rat Cathepsin B ELISA Kit (Colorimetric)

 

NBP1-91259

Human Cathepsin L ELISA Kit (Colorimetric)

 


基于新冠肺炎肺部病变的病理机制研发减轻肺部病变症状的药物

途游斗地主2003 NIAN SARS QIJIAN,YOUYANJIUFAXIANHUANZHEXUEQINGZHONGSHANGDIAODEXIBAOYINZIYUFEIBUYANZHENGHESUNSHANGCUNZAIMIQIEDEGUANLIAN。MERS HUANZHEYECHUXIAN IFNγ、TNFα、IL15 HE IL17 DENGXIBAOYINZIDESHANGDIAO。

JINQIWENZHANGBAODAOLE SARS-CoV-2 SUOZHIFEIYANHUANZHEXUEJIANGZHONGDEXIBAOYINZIFENMIQINGKUANG,GANRANBINGRENBIAOXIANCHUGAONONGDUDE IL-1β、IFN-γ、IP10 HE MCP1;ER ICU HUANZHEXUEJIANGZHONG IL-2、IL-7、IL-10、G-SCF、IP-10、MCP1、MIP1A HE TNF-αDENGXIBAOYINZISHUIPINGBIFEI ICU HUANZHEGENGGAO。

途游斗地主ZHEIXIEXINXIJUNANSHILEXIBAOYINZIDEFENMIQINGKUANGKENENGYUXINGUANFEIYANHUANZHEFEIBUBINGBIANDEYANZHONGCHENGDUXIANGGUAN。YINCI,LIYONGZHONGHEZUDUANKANGTIYAOHUOYIZHIJIJINXINGKANGXIBAOYINZIDELIAOFAKENENGSHIJIANQINGXIBAOYINZIFENGBAOYINQIDEFEISUNSHANG、DUOQIGUANSHINENGFANGFAZHIYI。

JUZHONGGUOLINCHUANGSHIYANZHUCEZHONGXINGUANWANGXIANSHI,ZAIXIBAOZHILIAOZHONGYONGYUYIZHIXIBAOYINZIFENGBAODETUOZHUDANKANGYIJINGDENGJILEYIXIANGZAIXINXINGGUANZHUANGBINGDUFEIYAN(COVID-19)ZHONGDEYOUXIAOXINGJIANQUANXINGDEDUOZHONGXIN、SUIJIDUIZHAOLINCHUANGYANJIU(ZHUCEHAO:ChiCTR2000029765)。

 

Bio-Techne 提供了与新冠肺炎相关的细胞因子系列产品辅助药物研发。

IL-1beta 重组蛋白

货号

品名

表达体系

201-LB

Recombinant Human IL-1 beta/IL-1F2 Protein

E. coli

201-GMP

Recombinant Human IL-1 beta/IL-1F2 GMP Protein, CF

E. coli

401-ML

Recombinant Mouse IL-1 beta/IL-1F2 Protein

HEK293T

IL-1beta 抗体

货号

品名

应用

MAB601

Human IL-1 beta /IL-1F2 Antibody

B/N, ELISA(Cap), ICC/IF, WB

AF-201-NA

Human IL-1 beta /IL-1F2 Antibody

B/N, Dual ISH-IHC, ICC/IF, IHC, WB

AF-401-NA

Mouse IL-1 beta /IL-1F2 Antibody

B/N, ICC/IF, IHC, Simple Western, WB

IL-1beta 小分子化合物

货号

品名

描述

1793

AF 12198

Potent, selective human type I IL-1 receptor antagonist

IFN-gamma 重组蛋白

货号

品名

表达体系

285-IF

Recombinant Human IFN-gamma Protein

E. coli

285-GMP

Recombinant Human IFN-gamma GMP Protein, CF

E. coli

485-MI

Recombinant Mouse IFN-gamma Protein

E. coli

IFN-gamma 抗体

货号

品名

应用

MAB285

Human IFN-gamma Antibody

B/N, Flow, ICC/IF

MAB2852

Human IFN-gamma Antibody

B/N, ELISA(Cap), Flow, WB

MAB485

Mouse IFN-gamma Antibody

B/N, CyTOF-ready, Flow, WB

IFN-gamma 小分子化合物

货号

品名

描述

4656

(D)-(+)-Neopterin

Stimulated by IFN-γ; marker of immune activation

IP-10/CXCL10 重组蛋白

货号

品名

表达体系

266-IP

Recombinant Human CXCL10/IP-10 Protein

E. coli

466-CR

Recombinant Mouse CXCL10/IP-10/CRG-2 Protein

E. coli

IP-10/CXCL10 抗体

货号

品名

应用

MAB266

Human CXCL10/IP-10/CRG-2 Antibody

B/N, CyTOF-ready, ELISA(Cap), Flow

AF-266-NA

Human CXCL10/IP-10/CRG-2 Antibody

B/N, CyTOF-ready, ELISA, Flow, ICC/IF, IHC

AF-466-NA

Mouse CXCL10/IP-10/CRG-2 Antibody

B/N, IHC, WB

MCP-1 重组蛋白

货号

品名

表达体系

279-MC

Recombinant Human CCL2/MCP-1 Protein

E. coli

479-JE

Recombinant Mouse CCL2/JE/MCP-1 Protein

E. coli

NBP1-81837PEP

CCL2/MCP1 Recombinant Protein Antigen

E. coli

MCP-1 抗体

货号

品名

应用

MAB679

Human CCL2/JE/MCP-1 Antibody

B/N, ELISA(Cap), IHC, WB

AF-279-NA

Human CCL2/JE/MCP-1 Antibody

B/N, IHC, WB

AB-479-NA

Mouse CCL3/MIP-1 alphaAntibody

B/N, WB

G-CSF 重组蛋白

货号

品名

表达体系

214-CS

Recombinant Human G-CSF Protein

E. coli

414-CS

Recombinant Mouse G-CSF Protein

E. coli

G-CSF 抗体

货号

品名

应用

MAB214

Human G-CSF Antibody

B/N, ELISA(Cap)

AF-214-NA

Human G-CSF Antibody

B/N, WB

MAB414

Mouse G-CSF Antibody

B/N, ELISA(Cap), Flow, WB

MIP1a 重组蛋白

货号

品名

表达体系

270-LD

Recombinant Human CCL3/MIP-1 alpha Protein

E. coli

450-MA

Recombinant Mouse CCL3/MIP-1 alpha Protein

E. coli

MIP1a 抗体

货号

品名

应用

AF-270-NA

Human CCL3/MIP-1 alpha Antibody

B/N, ELISA(Cap), IHC, WB

MAB670

Human CCL3/MIP-1 alpha Antibody

B/N, ELISA

AF-450-NA

Mouse CCL3/MIP-1 alpha Antibody

B/N, ELISA(Cap), ICC/IF, IHC, WB

TNFa 重组蛋白

货号

品名

表达体系

210-TA

Recombinant Human TNF-alpha Protein

E. coli

210-GMP

Recombinant Human TNF-alpha GMP Protein, CF

E. coli

410-MT

Recombinant Mouse TNF-alpha (aa 80-235) Protein

E. coli

TNFa 抗体

货号

品名

应用

AF-410-NA

Human/Mouse TNF-alpha Antibody

B/N, CyTOF-ready, ELISA(Cap), Flow, ICC/IF, WB

MAB610

Human TNF-alpha Antibody

B/N, ELISA(Cap), ICC/IF, WB

AB-410-NA

Mouse TNF-alpha Antibody

B/N, WB

TNFa 小分子化合物

货号

品名

描述

5484/10

C 87

TNF-α inhibitor

IL-4 重组蛋白

货号

品名

表达体系

204-IL

Recombinant Human IL-4 Protein

E. coli

204-GMP

Recombinant Human IL-4 GMP Protein, CF

E. coli

404-ML

Recombinant Mouse IL-4 Protein

E. coli

IL-4 抗体

货号

品名

应用

MAB204

Human IL-4 Antibody

B/N, WB

MAB304

Human IL-4 Antibody

B/N, ICC/IF, WB

MAB404

Mouse IL-4 Antibody

B/N, ELISA(Cap), WB

IL-7 重组蛋白

货号

品名

表达体系

207-IL

Recombinant Human IL-7 Protein

E. coli

207-GMP

Recombinant Human IL-7 GMP Protein, CF

E. coli

407-ML

Recombinant Mouse IL-7 Protein

E. coli

IL-7 抗体

货号

品名

应用

MAB207

Human IL-7 Antibody

B/N, ELISA(Cap), WB

AF-207-NA

Human IL-7 Antibody

B/N, WB

AF407

Mouse IL-7 Antibody

B/N, ELISA(Cap), WB

VEGF 重组蛋白

货号

品名

表达体系

293-VE

Recombinant Human VEGF 165 Protein

Sf 21 (baculovirus)

493-MV

Recombinant Mouse VEGF 164 Protein

Sf 21 (baculovirus)

VEGF 抗体

货号

品名

应用

MAB293

Human/Primate VEGF Antibody

B/N, ELISA(Cap), WB

AF-293-NA

Human VEGF 165 Antibody

B/N, ICC/IF, IHC, WB

AF-493-NA

Mouse VEGF 164 Antibody

B/N, ELISA(Cap), IHC, WB

小分子化合物

货号

品名

描述

(E)-FeCP-oxindole

Selective VEGFR-2 inhibitor

2542/10

Ki 8751

Potent, selective VEGFR-2 inhibitor

 

CHUBENWENCEZHONGDEYAOWUYANFA,GUANYUXINGUANFEIYANDEKEFANGKEKONGKEZHI,BEISHOUGUANZHUDEHAIYOUGANXIBAOZHILIAOJIYIMIAOKAIFA,SANGUANQIXIA,QIDAICHUNHUIDADI,YIQINGBUZAI。

 

以上内容来源于Bio-techne

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