途游斗地主

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途游斗地主XINGUANYANJIUBIBEIGANHUO | SARS-CoV-2 BIANMADANBAIYIWANGDAJIN

JINRI,BEIJINGDEXINFADICHUXIANDUOGEXINGUANFEIYANBENTUQUEZHENBINGLI,RANGZHUJIANPINGJINGDEGUONEIYIQINGXINGSHIZAIDUJINZHANGQILAI。

QIJINWEIZHISHANGWEIZHAODAODUIKANG SARS-CoV-2 DETEXIAOBANFA,YAOWUJIYIMIAODEYANFAZHENGZAIJINZHANGDEKAIZHANZHONG,QUANMIANJIEXI SARS-CoV-2,JIEKAIDANBAIMIMA,SHIYANFADEZHONGYAOQIANTI。BENWEN,WOMENDAQIDI SARS-CoV-2 BIANMADANBAIYU SARS-CoV DANBAIDETONGYUANXING、FENLEIJIGONGNENG。

 

非结构蛋白与结构蛋白

途游斗地主SARS-CoV-2 SHIYIZHONGYUE 30kb DEYANGXINGDANLIAN RNA BINGDU,QIJIYINZUZUCHENGYU SARS-CoV XIANGSI,LIANGZHEDOUSHIYOULIANGGEZHUYAODEKAIFANGYUEDUKUANG(ORF)HEJIGEJIAOXIAODEXIAYOU ORF ZUCHENG。

LIANGGEZHUYAODE ORF(ORF1a HE ORF1b)BIANMALIANGGEDUOTAI,BEIBINGDUBIANMADEDANBAIMEIQIEGEHOUCHANSHENGFEIJIEGOUDANBAI(nsps)。ORF1a BIANMA 440-500 kDa DUOTAI(pp1a),GAIDUOTAIJINGGUOMEICHULILIEJIECHENG 11 GE  nsps。ORF1b BIANMA 740-810 kDa DEJIAODADUOTAI(pp1ab),GAIDUOTAIBEIQIEGEWEI 16 GE nsps。

途游斗地主ZAI SARS-CoV-2 ZHONGYIJIANDINGCHUSIZHONGZHUYAODEJIEGOUDANBAI,BAOKUOCITUDANBAI、HEYIQIAODANBAI、MODANBAIHEBAOMODANBAI,YU SARS-CoV JUYOUXIANZHUDETONGYUANXING。ZHEISIGEJIEGOUDANBAIYOU ORF2-10 BIANMA,SHIBINGDUXINGCHENGWAIQIAOHEJIYINZUYIQIAOHUASUOBIXUDE。YUFEIJIEGOUDANBAIXIANGBI,JIEGOUDANBAINENGYINFAGENGGAOSHUIPINGDETIYEMIANYIHEXIBAOMIANYIFANYING。

 

结构蛋白之刺突蛋白

SARS-CoV-2 DECITUDANBAISHIBINGDUBIAOMIANDETANGDANBAI,YOULIANGGEZHUYAOGONGNENGJIEGOUYU S1(14-667 aa)HE S2(668-1255 aa)ZUCHENG,FENBIEJIEDAOYUSUZHUXIBAOSHOUTIJIEHEHEMORONGHE。BINGDUDEFUZHEHEJINRUSUZHUXIBAOQUJUEYUCITUDANBAIDESHOUTIJIEHEYU(RBD:306-527aa)YUTEDINGXIBAODANBAIDEXIANGHUZUOYONG。

YANJIUBIAOMING,XUEGUANJINZHANGSUZHUANHUAMEI 2(ACE-2)HEDANBAIMEI TMPRSS2 FENBIESHI SARS-CoV-2 JINRUSUZHUXIBAOSUOXUDEXIBAOSHOUTIHEDANBAIMEI。BAXIANG ACE-2 DEKANGTI(ZHONGHEKANGTI AF933,21 Citations),YOUWANGCHENGWEIZHILIAOXINGUANFEIYANDEYOUXIAOFANGFAZHIYI。

DANBAIMEI TMPRSS2 HE/HUO cathepsin L ZAI S1-S2 LIANJIECHUQIEGECITUDANBAI,CONGERSHIBINGDUBAOMOYUXIBAOMORONGHE,CUSHIBINGDU RNA JINRUXIBAO。SARS-CoV-2 YEKEYIBEI furin DANBAIMEIQIEGE,QISHIBIE S1-S2 LIANJIECHUDESIGEANJISUANXULIE。CHULEZAI S1-S2 LIANJIECHUQIEGECITUDANBAIWAI,XIBAODANBAIMEIHAIKEYIJIANQIE S2 YAJI,ZHEIDUIYUCITUDANBAIDEJIHUOHESUIHOUDEMORONGHEZHIGUANZHONGYAO。

✦ SARS-CoV-2 YU SARS-CoV DECITUDANBAIXULIEBIJIAORUHE?

途游斗地主SARS-CoV-2 DEBIAOMIANTANGDANBAIHUOCITUDANBAIYU SARS-CoV DECITUDANBAIJUYOU 76% DEXULIETONGYUANXING。Novus Biologicals® TIGONGLEJIZHONGYONGYUJIANCE SARS-CoV CITUDANBAIDEKANGTI,ZHEIXIEKANGTIKEYONGYU WB、ICC / IF、ELISA DENGDUOZHONGYINGYONG。GENJUNovus DECHUANGXINJIHUA,BUFANGSHIYANQIZHONGDEKANGTIYONGYUJIANCE SARS-CoV-2。

 

用于检测 SARS-CoV 的刺突蛋白抗体:

 

结构蛋白之核衣壳蛋白

HEYIQIAODANBAI(419 aa)WEIYU SARS-CoV-2 BINGDUKELIDEHEXIN,BINGYUBINGDU RNA XIANGHUZUOYONG。ZAIBINGDUZUZHUANGGUOCHENGZHONG,HEYIQIAODANBAIZAIBAOZHUANGBINGDU RNA JIYINZUZHONGFAHUIZHEHEXINZUOYONG。SARS-CoV HEYIQIAODANBAIHAICANYUQITAGONGNENG,LIRUDIAOJIESUZHUDEXIBAOGUOCHENG,BAOKUOXIBAOZHOUQISHIDIAO、YIZHI IFN CHANSHENGHEYOUDAOCUYANYINZI(LIRU COX-2)CHANSHENGDENG。

✦ SARS-CoV-2 YU SARS-CoV ZHIJIANDEHEYIQIAODANBAIXULIEBIJIAORUHE?

途游斗地主SARS-CoV-2 YU SARS-CoV DEHEYIQIAODANBAIJUYOU 91% DEXULIETONGYUANXING。Novus Biologicals® TIGONGLEJIZHONGYONGYUJIANCE SARS-CoV HEYIQIAODANBAIDEKANGTI,ZHEIXIEKANGTIKEYONGYU WB、ICC / IF、ELISA DENGDUOZHONGYINGYONG。

 

用于检测 SARS-CoV 核衣壳蛋白的抗体:

 

ZUIJINMEIGUOGUOLIWEISHENGYANJIUYUANDEYIXIANGYANJIUCHENGGONGJIANLILE SARS-CoV-2 GANRANDEHENGHEHOUDONGWUMOXING,BINGLIYONGTUDUOKELONGKANG SARS-CoV HEYIQIAOKANGTI(HUOHAO NB100-56576)CHENGGONGJIANCELE SARS-CoV-2 BINGDUZAIGANRANZUZHIZHONGDECUNZAI。

途游斗地主GANRAN SARS-CoV-2 DEHENGHEHOUDEBINGLIBIANHUA。TONGGUOMIANYIZUHUAJIANCEYIXIAXIBAO/ZUZHIZHONGDE SARS-CoV-2 HEYIQIAOKANGYUAN:(g)Ⅰ XINGFEIPAOXIBAO;(j)Ⅰ XINGFEIPAOXIBAO,Ⅱ XINGFEIPAOXIBAOJIFEIPAOJUSHIXIBAO;(k)ZONGGELINBAJIEHE(l)MANGCHANGGUYOUCENGZHONGDEJUSHIXIBAOHELINBAXIBAO。TUPIANYOU bioRxiv March 21, 2020// doi. org/ 10. 1101/ 2020. 03. 21. 001628  YIWEN Figure 4 XIUGAI。

 

最新 SARS-CoV-2 重组刺突蛋白及核衣壳蛋白:

 

结构蛋白之膜蛋白和包膜蛋白

途游斗地主MODANBAI(222 aa)HEBAOMODANBAI(75 aa)SHIZAIBINGDUBAOZHUANGZHONGFAHUIZUOYONGDEZHENGHEDANBAI。ZHONGSUOZHOUZHI,SARS-CoV DEMODANBAINENGSHI SARS HUANZHECHANSHENGZHONGHEKANGTI,ERBAOMODANBAIJIEDAO SARS-CoV DEDULI,BINGBANYANLIZITONGDAODEJIAOSE。

✦ SARS-CoV-2 YU SARS-CoV DEMODANBAIHEBAOMODANBAIXULIEBIJIAORUHE?

途游斗地主SARS-CoV-2 YU SARS-CoV DEMODANBAIJUYOU 91% DEXULIETONGYUANXING,BAOMODANBAIJUYOU 95% DEXULIETONGYUANXING。Novus Biologicals® TIGONGLEJIZHONGYONGYUJIANCE SARS-CoV NEIMODANBAIHEBAOMODANBAIDEKANGTI,ZHEIXIEKANGTIKEYONGYU WB、ICC / IF、ELISA DENGDUOZHONGYINGYONG。

用于检测 SARS-CoV 的内膜蛋白和包膜蛋白抗体:

 

非结构蛋白大揭秘

途游斗地主FEIJIEGOUDANBAI(nsps)ZAIBINGDUFUZHIZHOUQIZHONGFAHUIBUTONGDEGONGNENG,BIANMADE nsps(1-16)GONGTONGXINGCHENGDANBAIFUZHIMEI-ZHUANLUMEIFUHEWU。

 

途游斗地主✦ SARS-CoV nsp5 HE nsp13 DANBAIDEKANGTI

途游斗地主SARS-CoV-2 YU SARS-CoV DE nsp5 JUYOU 96% XULIETONGYUANXING,nsp13 JUYOU 99% DEXULIETONGYIXING。Novus Biologicals® TIGONGLEZHENDUI nsp5(NBP1-78110)HE nsp13(nbp2-89168)DANBAIDETUDUOKELONGKANGTI,ZHEIXIEKANGTIKEYONGYU WB、ICC / IF、ELISA DENGDUOZHONGYINGYONG。

途游斗地主GANRAN 6 XIAOSHIHOUDE Vero-E6 XIBAOZHONG,SHIYONGKANG SARS-CoV nsp13 TUDUOKELONGKANGTI(NBP2-89168)JINXINGMIANYIYINGGUANGXIANWEIJINGJIANCHA。

 

 

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